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Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic diseaseexcept leukemiain the presence of ZyloprimHoweverin a well-controlled study of patients with lymphoma on combination therapyZyloprim did not increase the marrow toxicity of patients treated with cyclophosphamidedoxorubicinbleomycinprocarbazineand/or mechlorethamine.

The most frequent adverse reaction to Zyloprim is skin rashSkin reactions can be severe and sometimes fatalThereforetreatment with Zyloprim should be discontinued immediately if a rash developssee WARNINGSSome patients with the most severe reaction also had feverchillsarthralgiascholestatic jaundiceeosinophilia and mild leukocytosis or leukopeniaAmong 55 patients with gout treated with Zyloprim for 3 to 34 monthsaverage greater than 1 yearand followed prospectivelyRundles observed that 3of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruptionsometimes scaly or exfoliativeHoweverwith current usageskin reactions have been observed less frequently than 1The explanation for this decrease is not obviousThe incidence of skin rash may be increased in the presence of renal insufficiencyThe frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with Zyloprim has been reported to be increasedsee PRECAUTIONS

Some less serious side effects of allopurinol may includeVomiting Diarrhea Drowsiness Headache Muscle pain Changes in sense or taste.

Hypersensitivity syndromeA severe allergic reaction called hypersensitivity syndrome has occurred for some people with the use of allopurinolThis reaction involves a number of organs in the body and may be fatal if not treated quicklyStop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reactionincluding feverswollen glandsyellowing of the skin or eyesor flu-like symptoms with skin rash or blistering.

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skin exam-ination reveals a diffuse purchase zyloprim 300 mg fast delivery, polymorphous rash with some plaques.