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During selection of first-line treatment options for pediatric schizophrenia and bipolar i disorder, consider the increased potential for pediatric patients to experience weight gain and elevated cholesterol or triglyceride concentrations from olanzapine treatment.
Information about Olanzapine.
FDA warningIncreased death and heart-related side effects in seniors with dementia-related psychosis.
Not approved for dementia-related psychosiselderly patients with dementia-related psychosis who are treated with antipsychotic drugs are at increased risk of deathas shown in short-term controlled trialsin these trialsdeaths appeared to be either cardiovasculare.gheart failuresudden deathor infectiouse.gpneumoniain nature.
Has potential to impair judgmentthinkingand motor skillsuse caution when operating machinery.
The conditions and duration of treatment with olanzapine varied greatly and includedin overlapping categoriesopen-label and double-blind phases of studiesinpatients and outpatientsfixed-dose and dose-titration studiesand short-term or longer-term exposureAdverse reactions were assessed by collecting adverse reactionsresults of physical examinationsvital signsweightslaboratory analytesECGschest x-raysand results of ophthalmologic examinations.
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therefore, caution is advised when administering olanzapine with drugs having an established causal association with qt prolongation and torsade de pointes tdp .