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As for the gastro-intestinal bleeding, cawkwell said pfizer is conducting three celebrex studies on stomach safety, and completion of the earliest study is at least a year away.
Information about Celebrex.
There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID useThe concurrent use of aspirin and an NSAIDsuch as celecoxibincreases the risk of serious gastrointestinalGIeventssee Gastrointestinal BleedingUlcerationAnd Perforation
Some adverse reactions occurred in higher percentages of patients than in the arthritis pre-marketing trialstreatment durations up to 12 weekssee Adverse events from CELEBREX pre-marketing controlled arthritis trialsaboveThe adverse reactions for which these differences in patients treated with CELEBREX were greater as compared to the arthritis pre-marketing trials were as follows:
The efficacy and safety of CELEBREX for JRA have not been studied beyond six monthsThe long-term cardiovascular toxicity in children exposed to CELEBREX has not been evaluated and it is unknown if the long-term risk may be similar to that seen in adults exposed to CELEBREX or other COX-2 selective and non-selective NSAIDssee BOXED WARNINGWARNINGS AND PRECAUTIONS
Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleedingThe concomitant use of Celecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug aloneSerotonin release by platelets plays an important role in hemostasisCase-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone.
Some adverse reactions occurred in higher percentages of patients than in the arthritis pre-marketing trialstreatment durations up to 12 weekssee Adverse events from CELEBREX pre-marketing controlled arthritis trialsaboveThe adverse reactions for which these differences in patients treated with CELEBREX were greater as compared to the arthritis pre-marketing trials were as follows:
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common side effects of celebrex include diarrhea, hypertension, and abnormal hepatic function tests.