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There are no adequate and well-controlled studies in pregnant patientsCRIXIVAN should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Initiation of CRIXIVANa CYP3A inhibitorin patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving CRIXIVANmay increase plasma concentrations of medications metabolized by CYP3AInitiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of CRIXIVANrespectivelyThese interactions may lead to:

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if therapy with indinavir is discontinued, increase the dosage of iloperidone to the original dose.