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Before using this medicationtell your doctor or pharmacist your medical historyespecially ofhistory of blood disorderssuch as leukemialow white blood cell countbowel problemssuch as paralytic ileusirritable bowel syndromebreathing problemsdiabetes/family history of diabeteshigh cholesterol/triglyceride levelsglaucomaheart problemskidney problemsliver problemsobesity/family history of obesityseizuresdifficulty urinatingfor exampledue to enlarged prostatebreathing trouble during sleepsleep apnea

Since untreated mental/mood problemssuch as schizophreniaschizoaffective disorderscan be a serious conditiondo not stop taking this medication unless directed by your doctorIf you are planning pregnancybecome pregnantor think you may be pregnantimmediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

A gradual reduction in dose by steps of 12.5 mg over a period of at least one weekpreferably twois recommended.

Substances known to have a substantial potential to depress bone marrow function must not be used concurrently with Clozarilsee section 4.3

For patients to receive this medicationall doctorspharmacistsand patients must agree tounderstandand carefully follow the requirements of the Clozapine REMS ProgramThese requirements apply in the United StatesIf you live in Canada or any other countryconsult your doctor and pharmacist for your country’s regulations.

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