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Inactive ingredients carboxymethylcellulose sodium, colloidal silicon dioxide, glycerol behenate, hydrogenated castor oil, hypromellose, lactose monohydrate, magnesium stearate, maltodextrin, mannitol, povidone, and one or more of the following fd c yellow no.
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Th commndd stating dos patints with congstiv hat ailu (NYHA Class I II) is 15 mg onc daily.
ACTOS, lik oth thiazolidindions, can caus dos-latd luid tntion whn usd alon in combination with oth antidiabtic mdications and is most common whn ACTOS is usd in combination with insulin. luid tntion may lad txacbat congstiv hat ailu. Patints should b obsvd signs and symptoms congstiv hat ailu. I congstiv hat ailu dvlops, it should b managd accoding tcunt standads ca and discontinuation dos duction ACTOS must b considd [s BOX WANING , CONTAINDICATIONS , and ADVS ACTIONS ].
ACTOS is indicatd as an adjunct tdit and xcis timpov glycmic contol in adults with typ 2 diabts mllitus in multipl clinical sttings [s Clinical Studis ].
ACTOS may caus dcass in hmoglobin and hmatocit. In placbo-contolld monothapy tials, man hmoglobin valus dclind by 2% t4% in patints tatd with ACTOS compad with a man chang in hmoglobin -1% t+1% in placbo-tatd patints. Ths changs pimaily occud within th ist 4 t12 wks thapy and maind lativly constant that. Ths changs may b latd tincasd plasma volum associatd with ACTOS thapy and a not likly tb associatd with any clinically signiicant hmatologic cts.
Pioglitazon may aly caus liv disas. Tll you doctight away i you dvlop symptoms liv disas, including: dak uin, yllowing ys/skin, psistnt nausa/vomiting, stomach/abdominal pain.
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nifedipine er co-administration of actos for 7 days with 30 mg nifedipine er administered orally once daily for 4 days to male and female volunteers resulted in least square mean 90 ci values for unchanged nifedipine of 0.